NDSC is a national membership organization that provides information, advocacy, and a strong self-advocate network for people with Down syndrome and their families. The organization hosts an annual national convention and produces resources covering education, health, and employment. Differentiator: membership-driven with a self-advocate council, complements NDSS's policy focus with family-to-family programming.

NDSS is the leading human rights organization for individuals with Down syndrome, advocating for policy change and providing resources from diagnosis through adulthood. The organization runs the National Buddy Walk Program and a national advocacy and policy center. Differentiator: Down syndrome-specific, strong on public awareness and federal legislative advocacy.

The National Federation of the Blind is the largest membership organization of blind individuals in the country, providing advocacy, training programs, and resources for blind and low-vision people of all ages. Local chapters offer mentoring and skills training, and the organization runs a national resource center and helpline. Differentiator: blind/low-vision specific, blind-led organization model.

The National Guardianship Association provides standards, certification, and education on guardianship and alternatives to guardianship for families considering decision-making support for an adult child with disabilities. The organization promotes person-centered planning and supported decision-making as alternatives to full guardianship where appropriate. Differentiator: focuses on guardianship alternatives and best practices, important given the trend toward supported decision-making over full guardianship.

The National Low Income Housing Coalition is a national advocacy and research organization focused on affordable housing for the lowest-income families in America. Families and advocates can access housing data, tenant rights information, and tools for finding affordable housing programs in their state. The site also tracks federal policy changes affecting housing assistance.